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  • Title: Pancreatic proteases and oxygen-derived free radicals in acute ischemic enteropathy.
    Author: Bounous G.
    Journal: Surgery; 1986 Jan; 99(1):92-4. PubMed ID: 3510480.
    Abstract:
    The specific susceptibility of the intestinal mucosa to low blood flow states is related to the "physiologic" makeup of the intestinal milieu. Pancreatic proteases appear to play a crucial role in the ischemic autodigestion of the intestinal mucosa. Moreover, trypsin can activate the conversion of xanthine dehydrogenase into superoxide radicals producing xanthine oxidase. Oxygen-derived free radicals account for at least part of the damage to the postischemic intestinal mucosa.
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