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  • Title: Designed inhibitors of horse liver alcohol dehydrogenase. Effect of active-site metal ion substitution.
    Author: Freudenreich C, Pfangert U, Weis M, Zeppezauer M, Biellmann JF.
    Journal: FEBS Lett; 1986 Feb 03; 196(1):160-2. PubMed ID: 3510908.
    Abstract:
    3-(p-Butoxyphenyl)propionamide, -thioamide and -hydrazide and the formamide of p-butoxybenzylamine were tested as inhibitors of cadmium(II) and cobalt(II) active-site substituted alcohol dehydrogenase. The results agree with a direct coordination of these inhibitors except for the hydrazide to the active-site metal ion, in the enzyme-NADH-inhibitor complex. The hydrazide might be situated at some distance from the metal ion without a direct coordination bond.
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