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  • Title: Neuronal differentiation of cloned human teratoma cells in response to retinoic acid in vitro.
    Author: Webb M, Graham C, Walsh F.
    Journal: J Neuroimmunol; 1986 Mar; 11(1):67-86. PubMed ID: 3511087.
    Abstract:
    We have analysed immunocytochemically the differentiation in vitro of clones of the human teratoma cell line Tera-2. The proliferating stem cells expressed Thy-1 and N-CAM/D2-CAM antigens. On treatment with 5 X 10(-5) M retinoic acid in either monolayer or aggregate cultures they began to express receptors for tetanus toxin and McAb A2B5. Three weeks after initiating retinoic acid treatment, the cultures contained a variety of cell morphologies, including about 3% of cells with a neuron-like morphology. These cells were reactive with tetanus toxin, McAb A2B5, and antibodies against Thy-1 and N-CAM/D2-CAM. They also expressed 55 000 and 210 000 Da neurofilament subunits.
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