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  • Title: Nitrogen-doped carbon quantum dots as fluorescent nanosensor for selective determination and cellular imaging of ClO.
    Author: Yang Z, Xu T, Zhang X, Li H, Jia X, Zhao S, Yang Z, Liu X.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2022 Apr 15; 271():120941. PubMed ID: 35114635.
    Abstract:
    The carbon nanomaterial based fluorescent probes have been widely applied in biological imaging. In the current research, we propose an interesting strategy for selective sensing of hypochlorite (ClO-) by a water-soluble and highly fluorescent nanosensor based on the N-doped carbon quantum dots (CDs) which was fabricated by a facile and environmental friendly hydrothermal approach from polyvinyl pyrrolidone, L-arginine and tryptophan. The structural characteristics of the probe were measured by multitudinous methods which proved the nanometer spherical structure of the probe and the successfully N-doping. Fluorescent investigation demonstrated that the probe is not only highly stable under interferences of pH, ionic strength, and irradiation, but also significantly selective toward ClO- amongst a variety of attractive bioactive species through the fluorescent quenching process which was correlative with the concentration of ClO- and linearly in the range of 0.1-50 μmol·L-1 with the sensitivity of 0.03 μmol·L-1. The probe can also be further illustrated in a prospective application for determination of ClO- in environmental water through both solution response and filer paper sensing. Moreover, the positive biocompatibility and ignorable cytotoxicity made the probe a promising effective agent for detection and visualizing ClO- in living cells which can facilitate the understanding the oxidative stress from the overexpressing ClO-.
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