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  • Title: Improvement in tardive dyskinesia after muscimol therapy.
    Author: Tamminga CA, Crayton JW, Chase TN.
    Journal: Arch Gen Psychiatry; 1979 May; 36(5):595-8. PubMed ID: 35117.
    Abstract:
    Muscimol, thought to be a agonist of gamma-aminobutyric acid (GABA), was administered to eight neuroleptic-free subjects with tardive dyskinesia. At oral dose levels from 5 to 9 mg, involuntary movements were consistently attenuated, usually in the absence of sedation. These results support the view that pharmacologic attempts to stimulate GABA-mediated synaptic transmission may afford symptomatic relief to patients with tardive dyskinesia.
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