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  • Title: Third generation cephalosporin antibiotics in surgical practice.
    Author: Fry DE.
    Journal: Am J Surg; 1986 Feb; 151(2):306-13. PubMed ID: 3511763.
    Abstract:
    The new third generation cephalosporins have a significantly greater spectrum of action against gram-negative bacteria likely to be encountered in surgical infections. This expanded spectrum may permit these drugs to be used in place of combination therapy in patients with polymicrobial infections; however, current evidence does not indicate superior results with these agents over earlier generation choices for surgical prophylaxis. The toxicity profile of these drugs warrants close monitoring for serious complications.
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