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  • Title: Anaphylactoid and systemic reactions following saline enema administration. Six case reports.
    Author: Lozynsky OA, Dupuis L, Shandling B, Gilmour RF, Zimmerman B.
    Journal: Ann Allergy; 1986 Jan; 56(1):62-6. PubMed ID: 3511778.
    Abstract:
    This report describes six children with spina bifida who have experienced a total of 13 episodes of generalized hives, angioedema and in two cases, anaphylactoid reactions immediately following saline enema infusions. The enemas were administered using a kit comprised of a plastic bag, tubing, and rectal end-piece. The reactions always occurred with the first use of new kits. A third child developed a systemic reaction with only the rectal end-piece in situ and without infusion of fluid. An in-hospital challenge using a new end-piece in one patient, who was clinically the most sensitive, produced an acute anaphylactoid reaction implicating the end-piece as the most likely source of the problem. The definitive mechanism(s) of the reactions and the agent(s) responsible for them presently remain unknown.
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