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  • Title: [Ecological and toxicological control over the status of the environment by the methods of physicochemical biology].
    Author: Kotelevtsev SV, Kozlov IuP, Stepanova LI.
    Journal: Nauchnye Doki Vyss Shkoly Biol Nauki; 1986; (1):19-30. PubMed ID: 3511976.
    Abstract:
    Xenobiotic metabolism in the fish liver has been investigated with a view of developing test-system for biomonitoring based on multienzyme membrane-bound complexes. Extraction methods of xenobiotics from harmful pollutants and some biological tissue have been described using various sorbents and solvents. The own and literary data on the study of mutagenic effect of this contaminants and carcinogens in the Ames test-system in the presence of postmitochondrial fraction S9 from fish liver with 3-methylcholanthrene induced by microsomal oxidation system have been demonstrated.
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