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  • Title: Manifestation of Panuveitis after Intraocular Surgery in a Child with Blau Syndrome.
    Author: Magliyah MS, Khan AM, AlShamrani M, Schatz P, Dhibi HA.
    Journal: Middle East Afr J Ophthalmol; 2021; 28(3):196-198. PubMed ID: 35125805.
    Abstract:
    Blau syndrome (BS) is a rare granulomatous disease with autosomal dominant inheritance. It is characterized by a triad of dermatitis, arthritis, and recurrent uveitis. This case presents the onset of panuveitis in BS after intraocular surgery. A 10-year-old boy presented to the outpatient clinic with retinal detachment in the left eye after 6 years following early-onset cataract surgery. Bilateral panuveitis occurred 3 weeks after surgical repair and resulted in a total visual loss in the left eye and was persistent to conventional treatment in the right eye. Genetic testing revealed a mutation in NOD2 gene. The addition of adalimumab to the treatment regimen resulted in long-term uveitis control and maintenance of 20/70 vision in the right eye. We propose that NOD2-mediated inflammatory cascade can be activated by intraocular surgery and results in the manifestation of BS.
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