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  • Title: The effect of gluten on HLA-DR in the small intestinal epithelium of patients with coeliac disease.
    Author: Ciclitira PJ, Nelufer JM, Ellis HJ, Evans DJ.
    Journal: Clin Exp Immunol; 1986 Jan; 63(1):101-4. PubMed ID: 3514010.
    Abstract:
    Frozen sections of control and coeliac jejunal mucosa were examined for HLA-DR staining. In general the staining pattern in the controls and treated coeliac patients was a patchy subapical pattern on villous tips. Untreated coeliac patients gave a different pattern with staining extending to the crypt enterocytes. Gluten challenge in three treated coeliac patients induced an altered staining pattern within 2 h.
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