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  • Title: Altered endothelium-mediated relaxation after denervation of growing rabbit ear artery.
    Author: Mangiarua EI, Bevan RD.
    Journal: Eur J Pharmacol; 1986 Mar 11; 122(1):149-52. PubMed ID: 3514241.
    Abstract:
    The relaxation response to methacholine and sodium nitroprusside was examined in ring segments from the posterior auricular artery and its continuation the central ear artery in growing rabbits 2, 4, 6 and 8 weeks following unilateral adrenergic and sensory denervation. The maximal relaxation achieved by methacholine (endothelium-dependent) was significantly depressed in the denervated arteries compared with the contralateral controls. Sodium nitroprusside (endothelium-independent relaxant agent) elicited the maximal relaxation in all tissues. These results demonstrated impaired arterial endothelium-dependent relaxation to methacholine after chronic denervation.
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