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  • Title: Human basement membrane components of keratoconus and normal corneas.
    Author: Millin JA, Golub BM, Foster CS.
    Journal: Invest Ophthalmol Vis Sci; 1986 Apr; 27(4):604-7. PubMed ID: 3514532.
    Abstract:
    Using immunofluorescence techniques, we analyzed the distribution of glycoproteins in normal and keratoconus corneas of humans. Laminin, bullous pemphigoid antigen, fibronectin, and fibrin/fibrinogen were all found in the epithelial basement membrane of normal corneas. Keratoconus corneas produced similar results, except that staining for fibrin/fibrinogen was weak. Fibrin/fibrinogen was absent from normal corneal basement membrane in animal models studied previously. Keratoconus may be the result of the lysis of fibrin or may involve impeded elaboration of fibrin.
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