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  • Title: A new butenolide with antifungal activity from solid co-cultivation of Irpex lacteus and Nigrospora oryzae.
    Author: Wu YM, Yang XQ, Chen JX, Wang T, Li TR, Liao FR, Liu RT, Yang YB, Ding ZT.
    Journal: Nat Prod Res; 2023 Jul; 37(13):2243-2247. PubMed ID: 35147448.
    Abstract:
    A new antifungal butenolide irperide (1) along with five known compounds were isolated from the co-culture of endophyte Irpex lacteus and pathogenic Nigrospora oryzae. The structure of 1, including the absolute configuration, was elucidated by analysis of NMR, HR-ESI-MS data and ECD spectra. Compounds 1, 4 and 6 exhibited significant antifungal activity against Aspergillus fumigatus, with MIC values of 1, 2 and 1 μg/mL, respectively.
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