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  • Title: [Immunomorphological study of fibronectin and collagen types I, III, IV and V in the myocardium in cardiosclerosis].
    Author: Shekhonin BV, Idel'son GL, Kotelianskiĭ VE, Chernousov MA, Sotnikov AV.
    Journal: Arkh Patol; 1986; 48(1):24-31. PubMed ID: 3516121.
    Abstract:
    Fibronectin and collagen, types I, III, IV and V, in the granulation tissue replacing the myocardial infarction, in the focal and diffuse cardiosclerosis were studied by means of the immunofluorescent method. The extracellular matrix in the granulation tissue contained fibronectin and collagen of the above types. Intracellular fibronectin was also found in the necrotized cardiomyocytes. Fibronectin and collagen of type IV were not detected in the postinfarction scars. The extracellular matrix consisted mainly of collagen, types III and V. Fibronectin and collagen, types I, III and V, are observed in the connective tissue in diffuse cardiosclerosis in the presence of the coronary arteries stenosis. No prevalence of the collagen of any type was found.
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