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  • Title: Alpha-Gal Syndrome: A New Etiology for Periorbital Edema.
    Author: Avila SA, Wojno T.
    Journal: Ophthalmic Plast Reconstr Surg; ; 38(4):e99-e100. PubMed ID: 35170570.
    Abstract:
    Alpha-gal syndrome is characterized by an IgE-mediated hypersensitivity response to the carbohydrate galactose-alpha-1,3-galactose. It can manifest as both an immediate drug allergy to pharmaceuticals containing alpha-gal as well as a delayed hypersensitivity response to the ingestion of mammalian meat products. In the United States, sensitization to alpha-gal is thought to occur from tick bites and can cause severe angioedema, most commonly periorbitally and periorally, with high rates of anaphylaxis. We present a unique case of chronic periorbital edema in a carnivorous individual after acquiring a new red meat allergy from Alpha-Gal Syndrome.
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