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  • Title: Pharmacologic induction of cholinergic system up-regulation and supersensitivity in affective disorders research.
    Author: Dilsaver SC.
    Journal: J Clin Psychopharmacol; 1986 Apr; 6(2):65-74. PubMed ID: 3517080.
    Abstract:
    Phenomenological, physiological, biochemical, and receptor binding measures are useful as dependent variables in affective disorders research. Abnormalities of these measures can result from up-regulation and supersensitivity of cholinergic systems and disturbances of cholinergic-monoaminergic interaction. These deviations are safely and inexpensively produced by pharmacologic induction of up-regulation and supersensitivity of central muscarinic cholinergic systems. Techniques for inducing these changes in cholinergic systems are reviewed, and principles governing their application to specific problems are illustrated.
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