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  • Title: Escherichia coli radC is deficient in the recA-dependent repair of X-ray-induced DNA strand breaks.
    Author: Felzenszwalb I, Sargentini NJ, Smith KC.
    Journal: Radiat Res; 1986 May; 106(2):166-70. PubMed ID: 3517933.
    Abstract:
    Escherichia coli K-12 cells incubated in buffer can repair most of their X-ray-induced DNA single-strand breaks, but additional single-strand breaks are repaired when the cells are incubated in growth medium. While the radC102 mutant was proficient at repairing DNA single-strand breaks in buffer (polA-dependent repair), it was partially deficient in repairing the additional single-strand breaks (or alkali-labile lesions) that the wild-type strain can repair in growth medium (recA-dependent repair), and this repair deficiency correlated with the X-ray survival deficiency of the radC strain. In studies using neutral sucrose gradients, the radC strain consistently showed a small deficiency in rejoining X-ray-induced DNA double-strand breaks, and it was deficient in restoring the normal sedimentation characteristics of the repaired DNA.
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