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  • Title: Maternal hypothyroidism reduces the expression of the kisspeptin/Kiss1r system in the maternal-fetal interface of rats.
    Author: Santos BR, Dos Anjos Cordeiro JM, Santos LC, de Oliveira LS, Mendonça LD, Santos EO, de Macedo IO, Szawka RE, Serakides R, Silva JF.
    Journal: Reprod Biol; 2022 Jun; 22(2):100615. PubMed ID: 35180577.
    Abstract:
    Alterations of circulating and placental levels of kisspeptin have been associated with gestational diseases. However, there are still no studies on the placental and decidual expression of Kiss1 and its receptor Kiss1r in maternal hypothyroidism, which is the aim of this work. We demonstrate that the fetoplacental restriction caused by hypothyroidism in rats is associated with a reduction in the Kiss1r expression and reduced Kiss1 and Kiss1r mRNA levels in the decidua and/or placenta. This demonstrate that fetoplacental restriction in hypothyroid rats is linked with a suppression of the kisspeptin/Kiss1r system at the maternal-fetal interface.
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