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  • Title: Triton X-114 phase separation of platelet membrane glycoproteins from normal subjects and a patient with type I thrombasthenia.
    Author: Khanduri U, Clark S, Walker ID, Chamberlain KG, Penington DG.
    Journal: Thromb Haemost; 1986 Feb 28; 55(1):98-103. PubMed ID: 3518135.
    Abstract:
    Surface-labelled normal and thrombasthenic platelets have been subjected to phase separation in Triton X-114. Triton-rich and Triton-poor fractions have been analysed by SDS-PAGE and IEF-SDS-PAGE. Partitioning characteristics of the major glycoproteins have been defined. The Triton-rich fraction contained GPIIb, III, IV, VI, VII, VIII, GP38 and the IIb beta subunit. In contrast, the Triton-poor fraction contained the HMWGP, GPIa, Ib, IIb, III, V and GPIX. Analysis of the platelet membrane glycoproteins of a patient with Type 1 thrombasthenia has been carried out using Triton X-114. The value of the method in diagnosis of this condition and differences between our findings and those published previously are discussed.
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