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  • Title: [Characteristics of the immune response of inoculated and intact animals to the administration of toxigenic and nontoxigenic strains of Clostridium tetani].
    Author: Shvarts SA, Stovbun SF, Bukova VE, Anisimova LA.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1986 Mar; (3):82-6. PubMed ID: 3518309.
    Abstract:
    In experiments on guinea pigs the immune reactions of the animals immunized and not immunized against tetanus in response to the injection of C. tetani spores were studied. In the immunized animals an increase in the production of tetanus antitoxin, the development of delayed hypersensitivity and the activation of the mechanisms of cell-mediated immunity were observed. The nonimmunized animals showed specific changes in the T-system of immunity without the appearance of the clinical symptoms of tetanus, which is, probably, one of the mechanisms of natural immunity.
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