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  • Title: The effect of lignocaine on nasal resistance and nasal sensation of airflow.
    Author: Jones AS, Lancer JM, Shone G, Stevens JC.
    Journal: Acta Otolaryngol; 1986; 101(3-4):328-30. PubMed ID: 3518333.
    Abstract:
    The effect of lignocaine on nasal sensation of airflow and nasal resistance was assessed in twenty-five subjects. A randomised crossover trial was conducted with lignocaine as the active drug and saline as the placebo. Both substances were delivered to the nasal mucosa as a nasal spray. Lignocaine caused a sensation of increased nasal patency in twenty-two of the twenty-five subjects studied. Saline had no such effect. The difference between this subjective effect of the two substances was highly significant (p less than 0.001). Neither spray had any significant effect on nasal resistance to airflow assessed objectively by rhinomanometry.
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