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  • Title: Efficacy and safety of pefloxacin in the treatment of patients with complicated urinary tract infections.
    Author: Boerema JB, Pauwels R, Scheepers J, Crombach W.
    Journal: J Antimicrob Chemother; 1986 Apr; 17 Suppl B():103-9. PubMed ID: 3519564.
    Abstract:
    One hundred and four patients with complicated urinary tract infections (prolonged severe chronic infections or with complicated postoperative conditions) were treated for ten days with pefloxacin 400 mg bid. Bacteriological eradication of the initial pathogen was achieved in 98% of the patients. After six weeks 93% of the patients were still free of the initial infecting microorganism. Clinical improvement was achieved in 77% of the patients five to seven days after cessation of treatment. The side-effects which were definitely related to pefloxacin occurred in 9% of patients and were mostly of a gastro-intestinal, a neurological, or an allergic nature. No significant biochemical or haematological adverse reactions occurred.
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