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  • Title: [Use of the hypotensive drug guanfacine in the treatment of patients with hypertension].
    Author: Kravchenko IG, Liashenko MM, Tarnakin AG, Chirkov SN.
    Journal: Kardiologiia; 1986 Mar; 26(3):41-5. PubMed ID: 3520085.
    Abstract:
    The hypotensive effect of guanfacin was evaluated in 39 essentially hypertensive patients aged 18 to 64 years and treated for 2 months. Their central, and peripheral hemodynamics, intracardiac kinetics and some humoral factors responsible for vascular tonicity control were also examined. The drug can be effective in patients with second- and third-stage essential hypertension, with a good hypotensive effect being obvious within 3-5 days of treatment (3 mg daily was the highest dose). In the course of treatment, general left-ventricular pump function returned to normal in 20 patients exhibiting a good hypotensive effect. Within 2 months of treatment, originally high plasma renin activity returned to normal, and the activity of angiotensin-converting enzyme declined.
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