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  • Title: Mitochondrial dysfunction and spinocerebellar degenerations.
    Author: Cedarbaum JM, Blass JP.
    Journal: Neurochem Pathol; 1986 Feb; 4(1):43-63. PubMed ID: 3520401.
    Abstract:
    A simplified classification of the spinocerebellar degenerations is proposed. Axonal ataxias include Friedreich's ataxia and other conditions involving, primarily, neurons with very long axons. Multiple system degenerations include the various olivopontocerebellar atrophies and related disorders. Ataxic encephalopathies are diffuse diseases of the nervous system in which ataxia is a prominent clinical feature. Several lines of data suggest that mitochondrial damage is a common mechanism in the spinocerebellar degenerations. Reasonable pathophysiological mechanisms can be invoked, linking mitochondrial damage to the observed pathologies (including the many cases of intermediate on variant forms).
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