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  • Title: Anthracycline antitumour agents. A review of physicochemical, analytical and stability properties.
    Author: Bouma J, Beijnen JH, Bult A, Underberg WJ.
    Journal: Pharm Weekbl Sci; 1986 Apr 25; 8(2):109-33. PubMed ID: 3520474.
    Abstract:
    A review of physicochemical and analytical properties of anthracycline antitumour agents is presented. The following subjects are discussed: protolytic equilibria, partition and partition coefficients, self-association, adsorptive properties, metal complexation, spectroscopy and chromatography. Furthermore, the stability of anthracyclines in solutions, in pharmaceutical preparations and in biological media is discussed.
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