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  • Title: Altered estrogen action in the senescent rat uterus: a model for steroid resistance during aging.
    Author: Roth GS.
    Journal: Adv Exp Med Biol; 1986; 196():347-60. PubMed ID: 3521224.
    Abstract:
    The estrogen stimulated rat uterus serves as a useful model to examine steroid resistance during aging. This system exhibits receptor loss, impaired stimulation of RNA polymerase II and defects in nuclear translocation (or enhanced association) of receptor-estradiol complexes. All of these defects appear to contribute in part to decreased estrogen responsiveness of the senescent rodent uterus.
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