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  • Title: Experimental hyperthyroidism does not induce hepatic insulin resistance in the miniature pig.
    Author: Müller MJ, Möring J, Seitz HJ.
    Journal: Biochem J; 1986 Mar 15; 234(3):537-41. PubMed ID: 3521590.
    Abstract:
    The effect of hypo- and hyper-thyroidism on insulin-mediated alterations in tracer-determined glucose kinetics and the arterial concentration of gluconeogenic precursors were investigated in 24 h-starved conscious unrestrained miniature pigs. Hyperinsulinaemia (about 40 microunits/ml) decreased blood glucose and, transiently, glucose output at unaltered glucose utilization in all thyroid states: this effect was pronounced in hyperthyroid (-50%) and less in hypothyroid pigs (-25%) compared with euthyroid controls (-35%). We conclude that moderate experimental hyperthyroidism does not induce hepatic insulin resistance, whereas hypothyroidism slightly impairs insulin action with respect to the regulation of glucose output.
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