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  • Title: Bactericidal effects induced by laser irradiation and haematoporphyrin against gram-positive and gram-negative microorganisms.
    Author: Martinetto P, Gariglio M, Lombard GF, Fiscella B, Boggio F.
    Journal: Drugs Exp Clin Res; 1986; 12(4):335-42. PubMed ID: 3522156.
    Abstract:
    Laser irradiation of tissues treated in vivo with haematoporphyrin (Hpr) is known to result in a cytocidal effect, reportedly more pronounced in tumour tissues. To ascertain whether this cytocidal phenomenon can occur not only in eukaryotic but also in prokaryotic cells, the authors devised a model system in vitro consisting of bacterial cultures in liquid and in solid media. Bacteria photosensitized with Hpr were subsequently exposed to laser beams and to daylight; then normal microbiological techniques were used to determine whether any bactericidal effect occurred. Satisfactory results were achieved, particularly against Gram-positive microorganisms; a partial inhibition of Gram-negative microorganisms was also observed.
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