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  • Title: [Effect of estrone on formation of the focus of heterotopic hematopoiesis].
    Author: Almazov VA, Arkad'eva GE, Zaritskiĭ AIu, Ivasenko IN.
    Journal: Biull Eksp Biol Med; 1986 Jun; 101(6):753-5. PubMed ID: 3524702.
    Abstract:
    The effect of estrone injections on the heterotopic bone marrow organ formation was studied in (C57Bl X CBA)F1 mice by bone marrow shaft transplantation under the kidney capsule. Estrone injections resulted in femur marrow fibrosis, the increase in the weight of femur and heterotopic organ ossicle, drastic reduction in heterotopic organ cellularity. Depression of hemopoiesis in ectopic organ cannot be attributed to mechanical displacement of hemopoietic cells because a newly formed bone cavity under the kidney capsule was not closed. Thus, estrone had a detrimental effect on the creation of microenvironment in the heterotopic organ.
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