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  • Title: The migration and neurochemical differentiation of gamma-aminobutyric acid (GABA)-immunoreactive neurons in rat visual cortex as demonstrated by a combined immunocytochemical-autoradiographic technique.
    Author: Miller MW.
    Journal: Brain Res; 1986 Jul; 393(1):41-6. PubMed ID: 3524756.
    Abstract:
    The development of some cortical local circuit neurons was traced using a technique which combined immunocytochemistry to label gamma-aminobutyric acid-immunoreactive (GABA+) neurons and [3H]thymidine autoradiography to identify cells with similar times of origin. Double-labeled neurons (GABA+ neurons with autoradiographic silver grains over their nuclei) are evident only after migration is complete. GABA+ neurons born on gestational day 16 are first identified in layer VIa on postnatal day 0 and those born on day 19 are in layer III on postnatal day 6. The frequency of double-labeled neurons increases during the week following their appearance. Therefore, the migration and the neurochemical differentiation of GABA+ neurons follow inside-to-outside sequences.
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