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  • Title: Treatment of LD100 Escherichia coli septic shock with netilmicin and methylprednisolone in baboons.
    Author: Flournoy DJ, Archer LT, Beller BK, Passey R, Hinshaw LB.
    Journal: Med Microbiol Immunol; 1986; 175(4):221-7. PubMed ID: 3526104.
    Abstract:
    Treatment efficacy with netilmicin sulphate/methylprednisolone sodium succinate in a severe septic shock baboon model, using an LD100 of live Escherichia coli, was evaluated. All the animals treated with both netilmicin and methylprednisolone were permanent (greater than or equal to 7 days) survivors, whereas none of the untreated baboons lived more than 24 hours. These results indicate that, in a baboon model, netilmicin is an effective alternative to gentamicin (with methylprednisolone) in the treatment of severe septic shock.
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