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  • Title: [Immunodiagnostic studies in ovarian cancer using the leukocyte adherence inhibition test (LAI test). 1. Detection of cellular sensitization of peripheral blood lymphocytes using the LAI test].
    Author: Ludwig HJ, Storch H.
    Journal: Zentralbl Gynakol; 1986; 108(10):593-606. PubMed ID: 3526755.
    Abstract:
    34 patients with histological assured ovarian cancer were investigated with the direct chamber LAI-assay according to Halliday and Miller. As antigens we used KCl-extracts of ovarian cancer, fetal tissue and four other tumor associated antigens, A sensitivity of lymphocytes to ovarian cancer antigens (OCA) and fetal antigens (FA) was detected in the malignant group with significant differences p less than 0.0005 to the control group. The accuracy for OCA was 86% respectively 82% for FA. The LAI-assay has additional value for diagnosing of ovarian cancer. Difficulties in interpreting the individual LAI-assays results as well as false positive tests in the control group are discussed.
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