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  • Title: [Antimicrobial chemoprevention in colorectal interventions: a single parenteral dose at the start of surgery is adequate].
    Author: Hancke E, Marklein G, Jensen JC, Voigt U, Stute H, Berker-von-Schlichting C.
    Journal: Chirurg; 1986 Jun; 57(6):406-10. PubMed ID: 3527592.
    Abstract:
    The effectivity in reducing septic complications after colorectal operations of oral 1 g Neomycin plus 0.25 g Metronidazol t.i.d. on the last preoperative day vs. intravenous single dose 5 g Mezlocillin plus 0.5 g Metronidazole was tested by sequential medical plan. There was no statistically significant difference between both chemoprophylaxis groups (p = 0.10). It is concluded that the intravenous chemoprophylaxis should be preferred because of the lowest dosage and therefore the fewest side-effects.
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