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  • Title: Current approaches to measurement of insulin secretion.
    Author: Polonsky KS, Rubenstein AH.
    Journal: Diabetes Metab Rev; 1986; 2(3-4):315-29. PubMed ID: 3527618.
    Abstract:
    The studies reviewed in this article have indicated that C-peptide and insulin are cosecreted from the beta cell in equimolar concentration, that C-peptide does not undergo significant hepatic extraction, and that its MCR remains constant over the physiologic range of concentrations. Furthermore, the peripheral kinetics of distribution of C-peptide can be described by a two-compartment mathematical model. If model parameters are derived in individual subjects by analysis of C-peptide decay curves, this information can subsequently be used to derive insulin secretion rates with a great degree of accuracy from endogenously secreted C-peptide concentrations. The application of this approach to clinical research studies should greatly enhance our understanding of insulin secretion.
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