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  • Title: The measurement and validation of the nonsteady-state rates of C-peptide appearance in the dog.
    Author: Morishima T, Pye S, Polonsky K, Radziuk J.
    Journal: Diabetologia; 1986 Jul; 29(7):440-6. PubMed ID: 3527843.
    Abstract:
    In order to verify the calculation of nonsteady rates of secretion of C-peptide, dog C-peptide was infused into 5 normal conscious dogs at varying rates. Using the decay curve obtained following a preliminary injection of C-peptide in each animal, concentrations during the infusion, and mathematical deconvolution, the rate of appearance of the C-peptide was calculated. This rate was within 12% of the infusion rates, with 94% of the C-peptide infused recovered in the calculation. The metabolic clearance of C-peptide was calculated to be 10.1 +/- 1.0 ml/min following both its injection and constant infusion. In conclusion, within the limits of the errors determined, C-peptide and therefore insulin secretion can be calculated on a continuous basis under nonsteady-state conditions.
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