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  • Title: Mutagenicity of the non-carcinogenic dibenzylnitrosamine and an alpha-acetoxy derivative.
    Author: Jacobson MK, Barton RA, Yoder SS, Sigh S, Lyle RE.
    Journal: Cancer Lett; 1979 Feb; 6(2):83-7. PubMed ID: 35280.
    Abstract:
    The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrosamine (I), and a chemically synthesized alpha-acetoxy derivative, N-(alpha-acetoxy-benzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535. Compound (I) was non-mutagenic when tested directly or in the presence of a metabolic activation system while (II) was highly mutagenic when tested directly. This is the first report on the conversion of a non-mutagenic N-nitrosamine to a mutagen by the formation of an alpha-acetoxy derivative.
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