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  • Title: Myelopeptides--bone marrow mediators with immunostimulating and endorphin-like activity.
    Author: Petrov RV, Mikhailova AA, Zakharova LA, Vasilenko AM, Katlinsky AV.
    Journal: Scand J Immunol; 1986 Sep; 24(3):237-43. PubMed ID: 3529364.
    Abstract:
    Bone marrow cells produce soluble mediators with structural and functional heterogeneity. They were found to stimulate antibody production at the peak of the immune response, owing to compounds of a peptide nature (Mr 2000-1300). Active material was isolated by means of gel chromatography and electrophoresis. This material positively reacts with ninhydrin, and has maximum absorption close to 278 nm. Its antibody-stimulating activity decreased or stopped completely after treatment with proteolytic enzymes. Apart from the immunostimulating activity, bone marrow mediators have opiate-like activity. They have an analgetic effect, and interact with the opiate receptors of brain nerve cells. After a physicochemical and functional analysis, we conclude that bone marrow produces regulatory peptides that were previously unknown. We called them myelopeptides.
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