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  • Title: A double blind study with melperone and placebo in the treatment of chronic alcoholics.
    Author: Carlsson C, Gullberg B.
    Journal: Int J Clin Pharmacol Biopharm; 1978 Jul; 16(7):331-2. PubMed ID: 352974.
    Abstract:
    In a 2-wk randomized double blind study 60 chronic alcoholics were treated with either melperone (Buronil) or placebo. The patients were assessed daily using a scale including 4 items: tension, depression, craving and sleep. Statistically significant improvement was achieved in the placebo group only for "tension" and "sleep"; whereas, in the melperone group all four items improved significantly. Comparison between the groups revealed statistically significant superiority of melperone over placebo for the item "craving".
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