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  • Title: Three types of swine immunoglobulin-producing tumours: lymphoplasmacytic lymphosarcoma, immunoblastic lymphosarcoma and plasmacytoma.
    Author: Kadota K, Nemoto K, Mabara S, Shirai W.
    Journal: J Comp Pathol; 1986 Sep; 96(5):541-50. PubMed ID: 3531251.
    Abstract:
    Three types of swine immunoglobulin-producing tumours are described. Case 1 was a lymphoplasmacytic lymphosarcoma, in which IgG was intracellularly identified in the plasmacytoid cells. Case 2 was an immunoblastic lymphosarcoma, the large cells of which possessed intracytoplasmic IgG and well developed RER. Case 3 was diagnosed as a plasmacytoma. There were two distinct immunoglobulins, IgG and IgA, in single plasmacytoid cells and the RER was highly developed. The origins of the three cases are discussed according to the theory of B-lymphocyte differentiation sequences and the origins of B-cell lymphomas. The mechanism of "double producers" is discussed with reference to DNA and RNA.
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