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  • Title: [Captopril in the treatment of arterial hypertension in chronic nephritis].
    Author: Kutyrina IM, Rogov VA, Lifshits NL, Klepikov PV.
    Journal: Ter Arkh; 1986; 58(8):92-6. PubMed ID: 3532416.
    Abstract:
    The effect of captopril on arterial pressure, indices of renal function and renal function regulating factors was studied in 13 patients suffering from chronic glomerulonephritis with arterial hypertension. Captopril considerably decreased the expression of hypertension irrespective of the initial status of the renin-angiotensin-aldosterone system. A prolonged use of captopril resulted in an increase in the renal blood flow, a considerable decrease in the resistance of the renal vessels. A transient decrease in a glomerular filtration value was noted on the first days of treatment. The use of captopril did not cause significant changes in sodium balance; potassium excretion with urine decreased, its concentration in the blood increased. Captopril caused a sharp increase in the blood renin activity, a decrease in aldosterone production and excretion and an increase in the synthesis of renal prostaglandins. Captopril was well tolerated by the patients, noticeable side effects were undetectable. Mechanisms of the hypotensive effect of the drug and mechanisms of its action on renal function were discussed.
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