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  • Title: Pattern analysis of antidepressant response to fluoxetine.
    Author: Fieve RR, Goodnick PJ, Peselow ED, Barouche F, Schlegel A.
    Journal: J Clin Psychiatry; 1986 Nov; 47(11):560-2. PubMed ID: 3533909.
    Abstract:
    Seventy patients with unipolar major depressive disorder were treated with fluoxetine or placebo in a 6-week double-blind trial and were evaluated by changes in scores on the Hamilton Rating Scale for Depression (HAM-D) and the global improvement measure of the Clinical Global Impressions (CGI) scale. High correlations were found between the changes in HAM-D scores from baseline to endpoint and the final CGI improvement ratings. In patients with moderate depression (baseline HAM-D score of 20 or more), the differences in endpoint analysis between active treatment and placebo groups were significant. A persistent pattern of improvement was noted in 27% of those receiving fluoxetine but in none of those receiving placebo. Physician and patient evaluations as determined by the improvement measure of the CGI were closely correlated.
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