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  • Title: Current concepts and perspectives of renal volume regulation in relationship to hypertension.
    Author: Guyton AC, Manning RD, Norman RA, Montani JP, Lohmeier TE, Hall JE.
    Journal: J Hypertens Suppl; 1986 Oct; 4(4):S49-56. PubMed ID: 3534185.
    Abstract:
    The renal-body fluid mechanism for arterial pressure control is almost certainly the most primitive of all the pressure-regulating mechanisms in animals. Through the stages of evolution, the system has been greatly improved. Nervous controls provide rapid pressure-control mechanisms that function almost instantaneously, many hours or days before the renal-body fluid mechanism can act fully. The renin-angiotensin-aldosterone system plays another important role: this system ensures that very large changes in salt intake, from as little as one-tenth normal up to as high as 10 times normal, have very little effect on the regulated level of the arterial pressure. Finally, the long-term autoregulatory mechanism helps to dissociate the long-term control of cardiac output from long-term control of arterial pressure; it also makes it possible for extremely slight increases in body fluid volume to cause chronic volume-loading hypertension.
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