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Title: Necrotic Uveal Melanoma Mimics Orbital Cellulitis: A Review. Author: Abdel-Aty A, Linderman WL, Kombo N, Sinard J, Pointdujour-Lim R. Journal: Ocul Oncol Pathol; 2022 Feb; 8(1):1-8. PubMed ID: 35356597. Abstract: BACKGROUND: Uveal melanoma is the most common primary intraocular malignancy in adults, often resulting in painless vision loss. We report a case of necrotic uveal melanoma presenting with orbital inflammation mimicking orbital cellulitis and present a comprehensive review of the literature and tabulation of reported cases. SUMMARY: Our review found 44 published reports of spontaneously necrotic uveal melanoma involving 55 patients. Of these reports, 26 patients (47%) presented with orbital cellulitis. Presenting symptoms of necrotic uveal melanoma with orbital cellulitis included proptosis (82.8%), pain (80.7%), vision loss (61.5%), and restricted extraocular movements (46.2%). KEY MESSAGES: Uveal melanoma can rarely mimic orbital cellulitis. Autoinfarction and tumor necrosis causes secondary orbital inflammation. Intraocular malignancy must remain in the differential for patients with orbital inflammation and vision loss.[Abstract] [Full Text] [Related] [New Search]