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  • Title: Permanganate Oxidation of Organic Contaminants and Model Compounds.
    Author: Laszakovits JR, Kerr A, MacKay AA.
    Journal: Environ Sci Technol; 2022 Apr 19; 56(8):4728-4748. PubMed ID: 35356836.
    Abstract:
    Permanganate oxidation is an attractive environmental remediation strategy due to its low cost, ease of use, and wide range in reactivity. Here, permanganate reactivity trends are investigated for model organic compounds and organic contaminants. Second-order permanganate reaction rate constants were compiled for 215 compounds from 82 references (journal articles, conference proceedings, master's theses, and dissertations). Additionally, we validated some phenol rate constants and contribute a few additional phenol rate constants. Commonalities between contaminant oxidation products are also discussed, and we tentatively identify several model compound oxidation products. Aromatic rings, alcohols, and ether groups had low reaction rate constants with permanganate. Alkene reaction sites had the highest reaction rate constants, followed by phenols, anilines, and benzylic carbon-hydrogen bonds. Generally, permanganate reactivity follows electrophilic substitution trends at the reaction site where electron donating groups increase the rate of reaction, while electron withdrawing groups decrease the rate of reaction. Solution conditions, specifically, buffer type and concentration, may impact the rate of reaction, which could be due to either an ionic strength effect or the buffer ions acting as ligands. The impact of these solution conditions, unfortunately, precludes the development of a quantitative structure-activity relationship for permanganate reaction rate constants with the currently available data. We note that critical experimental details are often missing in the literature, which posed a challenge when comparing rate constants between studies. Future research directions on permanganate oxidation should seek to improve our understanding of buffer effects and to identify oxidation products for model compounds so that extrapolations can be made to more complex contaminant structures.
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