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  • Title: Phosphine-Catalyzed Enantioselective (3+2) Annulation of Vinylcyclopropanes with Imines for the Synthesis of Chiral Pyrrolidines.
    Author: Zhang F, Dai X, Dai L, Zheng W, Chan WL, Tang X, Zhang X, Lu Y.
    Journal: Angew Chem Int Ed Engl; 2022 Jun 13; 61(24):e202203212. PubMed ID: 35357071.
    Abstract:
    A phosphine-catalyzed highly enantioselective and diastereoselective (up to 98 % ee and >20 : 1 dr) (3+2) annulation between vinylcyclopropanes and N-tosylaldimines has been developed, which allows facile access to a range of highly functionalized chiral pyrrolidines. Notably, this method makes use of vinylcyclopropanes as a synthon for phosphine-mediated asymmetric annulation reaction, which will offer new opportunities for potential applications of cyclopropanes substrates in phosphine-catalyzed organic transformations.
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