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  • Title: Effects of degranulation of mast cells on proliferation of mesenchymal cells in the mesentery of mice.
    Author: Hatanaka K, Imakita M, Go S, Yamamoto A.
    Journal: Cell Tissue Res; 1986; 246(1):53-6. PubMed ID: 3536117.
    Abstract:
    A mast-cell activator, compound 48/80, causes proliferation of mesenchymal cells in the mesentery of rats. Its effect on W/Wv mice deficient in mast cells was tested to determine whether the proliferation is mediated in the degranulation of mast cells. Incorporation of [3H]thymidine into mesenchymal cells in the mesentery of these mice with or without compound 48/80 was very small compared to their normal litter mates. However, bone marrow transplantation markedly enhanced the effect of compound 48/80, and resulted in an incorporation of [3H]thymidine almost comparable to that observed in normal mice. Our results provide evidence that mesenchymal cell proliferation is caused by a product secreted by mast cells when stimulated by compound 48/80.
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