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  • Title: A review of clinical studies carried out in Italy with almitrine bismesylate.
    Author: Grassi V, Tantucci C, Sorbini CA, Grassi C, Cerveri I, Rampulla C, Bottino G, Giacometti A, Blasi A, Pezza A.
    Journal: Eur J Respir Dis Suppl; 1986; 146():671-6. PubMed ID: 3536560.
    Abstract:
    The authors refer to a double-blind versus placebo multicentric study, carried out in Italy on 128 hypoxaemic patients suffering from COLD, with Almitrine bismesylate, a new chemoreceptor stimulant drug, given by mouth for a period of two months. Almitrine induced significant changes (p less than 0.001) of PaO2, with a mean increase of 7.6 mmHg, and of PaCO2, with a mean decrease of 4.1 mmHg, without variations of lung volumes and caliber of large and/or small airways. Almitrine, well tolerated within the time limits of this trial, seems an effective oral respiratory drug, acting through a favourable effect on V/Q mismatching due mainly to a reduction of the shunt effect, but also to an improvement of the ventilatory pattern.
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