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  • Title: Serum and cerebrospinal fluid acyclovir pharmacokinetics in a neonate with HSV-2 meningoencephalitis.
    Author: Shoji K, Saito J, Nagai Y, Hayakawa I, Oho Y, Kato H, Tao C, Funaki T, Yamada M, Ogimi C.
    Journal: J Infect Chemother; 2022 Aug; 28(8):1168-1171. PubMed ID: 35370079.
    Abstract:
    A neonatal patient with Herpes simplex virus type-2 meningoencephalitis was treated by high-dose intravenous acyclovir therapy. Serum and cerebrospinal fluid (CSF) concentrations were measured retrospectively, showing that the CSF-to-serum concentration ratio was 0.67-0.71, which was higher than the previously reported values in other age groups.
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