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  • Title: Transcription of DNA-histone complexes by yeast RNA polymerase B.
    Author: Karagyozov LK, Valkanov MA, Hadjiolov AA.
    Journal: Nucleic Acids Res; 1978 Jun; 5(6):1907-17. PubMed ID: 353733.
    Abstract:
    Transcription of denatured DNA complexed with histones (total, H1 or H2A/H2B/H3/H4) by yeast RNA polymerase B is investigated. Binding of histones to DNA restricts its template activity by decreasing the formation of active, heparin-resistant, RNA polymerase initiation complexes. The elongation of pre-initiated RNA on denatured DNA, complexed with histones, is possible, although resulting in somewhat shorter RNA chains. It is suggested that RNA polymerase B can elongate on a DNA strand covered with histones.
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