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  • Title: Monoclonal autoantibodies in Heymann nephritis.
    Author: Kimura S, Sakurai A, Morioka T, Matsui K, Nakamura T, Yakata M, Oite T, Shimizu F.
    Journal: Clin Exp Immunol; 1986 Jul; 65(1):28-33. PubMed ID: 3539425.
    Abstract:
    We have developed hybridoma cell lines, each of which secretes a monoclonal antibody (MoAb) to rat renal and hepatic tissue antigens, from Lewis rat with Heymann's nephritis. Three antibodies bind to the brush border of proximal tubular epithelium (BB), one in a fine net-like pattern (no. 3-11), another one in a coarse granular pattern (no. 1-8) and the third one in a typical pattern (no. 3-9). Three antibodies bind to glomerulus in characteristic patterns but not to BB. After repeated intravenous injections of MoAb (no. 3-11), granular mesangial deposits of rat IgG were observed and of MoAb (no. 1-8), fine granular deposition along capillary walls. These monoclonal autoantibodies should be of value in research on the mechanism of autoimmune membranous nephropathy.
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